My mods folder is 35GB in size, but because I use Mod Organizer, a vast majority of space is files that are overwritten by other mods, so the game is not loading that amount of data at all. I've run around the world and not noticed a single issue with performance, and went with 4k or 2k versions of any mod available. I'm planning to add a 1TB SSD exclusively for games, but haven't gotten around to it yet. I have a very similar set of mods similar to Scarecrow, and a very comparable system, and I get no noticable issue with performance, running around the world, in combat, and I've gone with 4k textures where possible.
Originally posted by Scarecrow:GraFix Texture Overhaul 2.1: